kansadobe wrote:Thank you for the post. Is it possible for you to translate this development into common language?
js_finland wrote:"Our findings that approximately half of the DCM affected Doberman Pinschers carry the risk-allele on CFA 5 indicate that this is a major, but not the only genetic risk factor for DCM in this breed. The lack of other association signals further suggests that the unexplained 50% DCM cases might be caused by several different genetic risk factors of small effect size, which cannot be detected with the currently available cohort sizes."
It seems that the European group doesn't put too much value on the WSU/VSGL findings of a mutation in a part of the genome encoding PDK-4 - their interpretentation is it's just one of the several different risk factors (which should not even have been detected with the currently available cohort sizes...) each having just a small effect on DCM in dobermans. It would be really interesting to see if/how the WSU/VSGL team will react...
jotunheim wrote:Are you saying, that the people behind the German paper, should make recommandations in regard to the WSU findings ?
Ronindobe wrote:I am a bit confused tho as to why if both labs were analysing across all the chromosones ...why didn't each see the other mutation? Is it a matter that the stopped at the first one they noticed? Any thoughts on this Sonia?
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