A new investigation of the genes associated with Dobermann DCM from group of University of Guelph-Canada, published July-2011, (http://avmajournals.avma.org/doi/abs/10.2460/ajvr.72.7.932
) show that an alpha-actinin gene variant, resulted in an amino acid change in the rod-forming triple coiled-coil domain, was detected in 40% of affected Dobermann (2/5) and may contribute to the development of DCM given its potential effect on the structure of this protein.
O'Sullivan ML, O'Grady MR, Pyle WG, Dawson JF (2011). Evaluation of 10 genes encoding cardiac proteins in Doberman Pinschers with dilated cardiomyopathy. Am J Vet Res.;72(7):932-9.
Alpha-actinin gene (ACTN1) is located in canine chromosome 8. Alpha-actinin is a cytoskeletal protein that in muscle cells is found at the Z-disk of sarcomeres where they help anchor the myofibrillar actin filaments.
This research illustrates newly the polygenic and complex nature of DCM in Dobermann.